| 酸化蒙脱土/氯化锌催化叔丁醚和叔丁酯的合成 |
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| 引用本文： | 吴剑虹,陈冬寅,李飞. 酸化蒙脱土/氯化锌催化叔丁醚和叔丁酯的合成[J]. 应用化学, 2016, 33(5): 565-570. DOI: 10.11944/j.issn.1000-0518.2016.05.150318 |
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| 作者姓名： | 吴剑虹 陈冬寅 李飞 |
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| 作者单位： | 南京医科大学药学院 南京 211166 |
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| 基金项目： | 国家自然科学基金(21172108)、江苏省高校自然科学研究项目(15KJB350002)、南京医科大学科技发展基金(2014NJMUZD019)项目资助 |
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| 摘 要： | 以酸化蒙脱土/氯化锌作为催化剂,二碳酸二叔丁酯与一系列酚、醇和羧酸类化合物在120 ℃封管条件下反应,合成了叔丁醚和叔丁酯类衍生物,方法简单,经济可靠,环境友好,后处理方便,收率为61%~75%,产物结构经1H NMR,ESI-MS确证。 探讨了溶剂、温度、金属离子等因素对反应收率的影响,并提出了可能的反应机理。 为今后该类化合物的合成提供了一种新的方法。
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| 关 键 词： | 酸化蒙脱土 氯化锌 叔丁酯 叔丁醚 有机合成 |
| 收稿时间： | 2015-08-31 |
Synthesis of tert-Butyl Ethers and tert-Butyl Esters Catalyzed by Acid-treated Montmorillonite Supported Zinc Chloride |
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| WU Jianhong,CHEN Dongyin,LI Fei. Synthesis of tert-Butyl Ethers and tert-Butyl Esters Catalyzed by Acid-treated Montmorillonite Supported Zinc Chloride[J]. Chinese Journal of Applied Chemistry, 2016, 33(5): 565-570. DOI: 10.11944/j.issn.1000-0518.2016.05.150318 |
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| Authors: | WU Jianhong CHEN Dongyin LI Fei |
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| Affiliation: | School of Pharmacy,Nanjing Medical University,Nanjing 211166,China |
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| Abstract: | With acid-treated montmorillonite supported zinc chloride(H-mont/ZnCl2) as the catalyst, phenols, alcohols, and carboxylic acid were reacted with di-tert-butyl dicarbonate to give tert-butyl ether and tert-butyl ester derivatives at 120 ℃ in sealed tube with yields ranging from 61% to 75%, which is simple and environmentally friendly. All the compounds synthesized were confirmed by 1H NMR and ESI-MS. The effect of solvent, temperature, metal ion and some other factors to the reaction were investigated. A possible mechanism for this reaction was proposed. Provided a new method for this type of synthesis in the future. |
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| Keywords: | acid-treated montmorillonite zinc chloride tert-butyl ethers tert-butyl esters organic synthesis |
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