| 离子液体Zn[CO(NH2)2]3Cl2介质中二肽催化醛的不对称α-氯代反应 |
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| 引用本文： | 张宝华,史兰香,刘胜宝. 离子液体Zn[CO(NH2)2]3Cl2介质中二肽催化醛的不对称α-氯代反应[J]. 应用化学, 2015, 32(7): 743-747. DOI: 10.11944/j.issn.1000-0518.2015.07.140383 |
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| 作者姓名： | 张宝华 史兰香 刘胜宝 |
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| 基金项目： | 河北省科技支撑项目(13964002D)、石家庄学院平台基金项目(XJPT007)资助 |
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| 摘 要： | 以二肽Pro-Trp为催化剂,2,3,4,5,6,6-六氯-2,4-环己二烯-1-酮为氯化剂,离子液体Zn[CO(NH2)2]3Cl2为溶剂,在N-甲基吗啉(NMM)存在下,各种醛能够高收率、较高立体选择性地完成羰基α-卤代反应,目标产物的产率可达到95%,对映选择性可达92%ee。 该方法具有操作简便、离子液体和催化剂可重复使用的优点。
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| 关 键 词： | 六氯-环己二烯-酮 离子液体 二肽 氯化 醛 |
| 收稿时间： | 2014-11-06 |
Dipeptide-Catalyzed Direct Asymmetric Chlorination of Aldehydes in Zn[CO(NH2)2]3Cl2 Ionic Liquid |
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| ZHANG Baohua,SHI Lanxiang,LIU Shengbao. Dipeptide-Catalyzed Direct Asymmetric Chlorination of Aldehydes in Zn[CO(NH2)2]3Cl2 Ionic Liquid[J]. Chinese Journal of Applied Chemistry, 2015, 32(7): 743-747. DOI: 10.11944/j.issn.1000-0518.2015.07.140383 |
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| Authors: | ZHANG Baohua SHI Lanxiang LIU Shengbao |
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| Affiliation: | College of Chemical Engineering,Shijiazhuang University,Shijiazhaung 050035,China;Baoding Traditional Chinese Medicine Pharmaco.,Itd,Baoding,Hebei 071200,China |
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| Abstract: | A method for direct asymmetric chlorination of aldehydes and 2,3,4,5,6,6-hexachloro-2,4-cyclohexadien-1-one catalyzed by Pro-Trp in the presence of N-methylmorpholine (NMM) and ionic liquid Zn[CO(NH2)2]3Cl2 has been developed. This method produces the corresponding optically active chlorinated products with high yields (up to 95%) and good enantioselectivities (up to 92%ee). The approach has advantages in simple isolation and reusablility of catalyst and ionic liquids. |
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| Keywords: | hexachloro-cyclohexadien-one ionic liquid dipeptide chlorination aldehyde |
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