In vitro alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide |
| |
| Authors: | Ueda Eriko Yoshikawa Yutaka Sakurai Hiromu Kojima Yoshitane Kajiwara Naemi M |
| |
| Institution: | Graduate School of Life Science, Kobe Women's University, Kobe, Japan. |
| |
| Abstract: | We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering effect in Zn(II) complexes with picolinamide derivatives in KK-A(y) mice. The Zn(II) complex showed strong alpha-glucosidase inhibitory activity greater by about eighty times (substrate: maltose) and forty times (substrate: sucrose) compared with acarbose. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
