A practical synthesis of alpha-aryl methyl ketones via a transition-metal-free Meerwein arylation |
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Authors: | Molinaro Carmela Mowat Jeffrey Gosselin Francis O'Shea Paul D Marcoux Jean-François Angelaud Rémy Davies Ian W |
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Institution: | Department of Process Research, Merck Frosst Centre for Therapeutic Research, 16711 Autoroute Transcanadienne, Kirkland, Québec, Canada H9H 3L1. carmela_molinaro@merck.com |
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Abstract: | We report herein a simple, scalable, transition-metal-free approach to the synthesis of alpha-aryl methyl ketones from diazonium tetrafluoroborate salts under mild conditions. This methodology uses easily accessible and nontoxic starting material and was applied to the multi-kilogram-scale preparation of 1-(3-bromo-4-methylphenyl)propan-2-one. |
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