Enantioselective desymmetrization of cyclopropenes by hydroacylation |
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| Authors: | Phan Diem H T Kou Kevin G M Dong Vy M |
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| Affiliation: | Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada. |
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| Abstract: | We report an enantioselective desymmetrization of cyclopropenes by intermolecular Rh-catalyzed hydroacylation. Cyclopropylketones, bearing quaternary stereocenters, are produced with diastereocontrol (up to >20:1) and excellent enantiomeric excess (up to >99 ee). |
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