Total synthesis of the Fusarium toxin equisetin |
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| Authors: | Burke Lisa T Dixon Darren J Ley Steven V Rodríguez Félix |
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| Affiliation: | Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW. |
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| Abstract: | A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels-Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted gamma,delta-unsaturated beta-ketothioester. |
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