Synthesis of 2-hydroxy-3-carbethoxy-5,6-dialkylpyrazines

Conclusions Some 2-hydroxy-3-carbethoxy-5,6-dialkylpyrazines were synthesized by reacting the hydrochlorides of -amino ketones with carbethoxyacetyl chloride in the presence of N,N-di-ethylaniline, azo-coupling the obtained N-(carbethoxyacetyl)--amino ketones with phenyldiazonium salt, and reduction of the intermediate N-(phenylhydrazonocarbethoxyacetyl)--amino ketones with zinc.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1067–1070, May, 1980.