| 二维平面细胞微图案化技术及其生物学应用 |
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| 引用本文： | 刘文文,陈振玲,蒋兴宇. 二维平面细胞微图案化技术及其生物学应用[J]. 分析化学, 2009, 37(7): 943-949. DOI: 10.1016/S1872-2040(08)60113-9 |
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| 作者姓名： | 刘文文 陈振玲 蒋兴宇 |
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| 作者单位： | 国家纳米科学中心,北京,100190;国家纳米科学中心,北京,100190;国家纳米科学中心,北京,100190 |
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| 基金项目： | 国家自然科学基金，国家重点基础研究发展规划(973计划)，百人计划;Corning公司以及中国博士后科学基金、王宽诚教育基金联合资助项目 |
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| 摘 要： | 可以控制细胞粘附形状、大小的方法统称为细胞图案化技术.这些方法结合微纳米制备、表面化学、电化学和光化学等手段可以动态控制细胞的粘附、迁移、分化及其相互作用,为细胞生物学研究提供了一个新平台.本文介绍了二维平面细胞图案化的各种方法,并对其优缺点进行了总结,评述了细胞图案化技术在细胞生物学基础研究、组织工程以及基于细胞的生物传感器领域的应用.
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| 关 键 词： | 细胞图案化 组织工程 细胞传感器 自组装单层膜 软刻蚀 评述 |
| 收稿时间： | 2009-02-07 |
Methods for Cell Micropatterning on Two-Dimensional Surfaces and Their Applications in Biology |
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| LIU Wen-Wen,CHEN Zhen-Ling,JIANG Xing-Yu. Methods for Cell Micropatterning on Two-Dimensional Surfaces and Their Applications in Biology[J]. Chinese Journal of Analytical Chemistry, 2009, 37(7): 943-949. DOI: 10.1016/S1872-2040(08)60113-9 |
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| Authors: | LIU Wen-Wen CHEN Zhen-Ling JIANG Xing-Yu |
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| Affiliation: | aNational Center for Nanoscience and Technology, Beijing 100190, China |
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| Abstract: | The technologies that we call as cell micropatterning allow the control of the shape and size of cell adhesion. Combination of micro/nano technology, surface chemistry, electrochemistry, and photochemistry enables us to control the adhesion, migration, differentiation of cells, and the interactions between different types of cells. These methodologies bring about a new platform for the studies of cell biology. This article reviews a number of techniques for cell patterning and compares their advantages and disadvantages. It also reviews certain applications of cell micropatterning, including those for fundamental studies in cell biology, tissue engineering, and cell-based biosensors. |
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| Keywords: | Cell micropatterning tissue engineering cell-based biosensors self-assembled monolayer soft lithography review |
| 本文献已被 CNKI 万方数据 ScienceDirect 等数据库收录！ |
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