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On differences between racemic and enantiomerically pure forms of aziridine-2-carboxamide* |
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| Authors: | M. Turks I. Rijkure S. Belyakov D. Zicāne V. Kumpiņš Ē. Bizdēna A. Meikas A. Valkna |
| Affiliation: | 1. Riga Technical University, 14/24 Azenes St., Riga, LV-1007, Latvia 2. Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga, LV-1006, Latvia 3. Institute for Gene Technology, Tallinn Technical University, 15 Akadeemia tee, Tallinn, 12618, Estonia 4. Competence Center for Cancer Research, 15 Akadeemia tee, Tallinn, 12618, Estonia |
| Abstract: | Synthesis, X-ray, and cytotoxicity studies of (S)- and (R)-aziridine-2-carboxamide (Leakadine) are described. X-ray data for the enantiomerically pure form are compared with those for racemic aziridine-2-carboxamide in order to explain the 21°C large melting point difference between both series. It was found that despite their overall low cytotoxicity (S)-aziridine-2-carboxamide is slightly more cytotoxic than (R)-aziridine-2-carboxamide. |
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