An enantioselective strategy to macrocyclic bisindolylmaleimides. An efficient formal synthesis of LY 333531 |
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| Authors: | Trost B M Tang W |
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| Institution: | Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@leland.stanford.edu |
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| Abstract: | reaction: see text]. The ability to employ a bromo alcohol as a nucleophile in a palladium-catalyzed dynamic kinetic asymmetric transformation leads to an efficient synthesis of a selective PKC inhibitor under clinical development. |
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