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Spectral localization of arbitrarily shaped regions of interest (SLASH) using single voxel signals |
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| Authors: | Zhiyue Wang Ravinder Reddy John C. Haselgrove Cheng-Yu Chen Gadi Goelman Robert A. Zimmerman John S. Leigh |
| Affiliation: | †Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA ‡Deparment of Radiology, Tri-Service General Hospital, Taiwan *Department of Radiology, University of Pennsylvania, Pennsylvania, PA 19104, USA |
| Abstract: | A method for obtaining localized spectra from arbitrarily shaped regions of interest is described. When a sample consists of homogeneous compartments or domains, spectra localized in each compartment can be obtained from signals of single voxels with regular shapes by solving a set of simultaneous linear equations. Experimental demonstrations on a phantom and on human brain in vivo for a two compartment, two voxel case are presented. The issue of signal-to-noise ratio is also discussed. |
| Keywords: | Magnetic resonance spectroscopy Localization Arbitrary shape Brain |
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