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Synthesis of fused imidazo azepine derivatives by sequential van Leusen/enyne metathesis reactions |
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| Authors: | Vijaya Gracias Alan F. Gasiecki Stevan W. Djuric |
| Affiliation: | aScaffold-Oriented Synthesis, Medicinal Chemistry Technologies, Abbott Laboratories, R4CP, AP10, 100 Abbott Park Road, Abbott Park, IL 60064-6099, USA |
| Abstract: | A facile synthesis of fused imidazo azepine derivatives by a van Leusen/intramolecular enyne metathesis synthetic sequence is reported. The two-step reaction sequence generates compounds of significant molecular complexity from simple starting materials in an expedient fashion with good overall yields. |
| Keywords: | Multicomponent reactions van Leusen Enyne metathesis |
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