Preparation of nanostructure hydroxyapatite scaffold for tissue engineering applications |
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Authors: | H Ghomi M H Fathi H Edris |
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Institution: | (1) Biomaterials Group, Department of Materials Engineering, Isfahan University of Technology, 8415683111 Isfahan, Iran |
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Abstract: | Hydroxyapatite due to its good biocompatibility and similar chemical composition to the mineral part of bone has found various
applications in tissue engineering. Porous hydroxyapatite has high surface area, which leads to excellent osteoconductivity
and resorbability, providing fast bone ingrowth. In this study, highly porous body of nanostructure hydroxyapatite was successfully
fabricated via gelcasting method. The pure phase of hydroxyapatite was confirmed by X-ray diffraction. The result of scanning
electron microscopy analysis showed that the prepared scaffold has highly interconnected spherical pores with a size in the
range 100–400 μm. The crystallite size of the hydroxyapatite scaffold was measured in the range 30–42 nm. The mean values
of true (total) and apparent (interconnected) porosity were calculated in the range 84–91 and 70–78%, respectively. The maximum
values of compressive strength and elastic modulus of the prepared scaffold were found to be about 1.5 MPa and 167 MPa, respectively,
which were achieved after sintering at 1,000 °C for 4 h. Transmission electron microscopy analysis showed that the particle
sizes are smaller than 80 nm. In vitro test showed good bioactivity of the prepared scaffold. The mentioned properties could
make the hydroxyapatite scaffold a good candidate for tissue engineering applications, especially applications that did not
need to stand any loading. |
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