Ultrasound-assisted click chemistry in continuous flow |
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| Authors: | Noah P. Tu Jill E. Hochlowski Stevan W. Djuric |
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| Affiliation: | (1) Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, 1983963113 Tehran, Iran;(2) Department of Chemistry, Shahid Beheshti University, G. C., Evin, 1983963113 Tehran, Iran |
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| Abstract: | We present a study on ultrasound-promoted click chemistry reactions in a meso-flow reactor synthesis system with a copper reactor and a custom sonication piezoelectric transducer. Copper catalyzed Huisgen 1,3-dipolar cycloadditions were studied in flow with this system. Our results demonstrate that 1,4-disubstituted 1,2,3-triazole products can be generated at low temperatures and with short reaction time in good yield, due to the rate enhancement effect of sonication. |
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