Synthesis of novel 4H-pyrimido[1,6-a]pyrimidines via a one-pot three-component condensation |
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| Authors: | Jinbao Xiang Hanghang Li Kai Yang Lang Yi Yongnan Xu Qun Dang Xu Bai |
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| Affiliation: | (1) The Center for Combinatorial Chemistry and Drug Discovery, The School of Pharmaceutical Sciences and The College of Chemistry, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, People’s Republic of China;(2) Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People’s Republic of China; |
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| Abstract: | Abstract Highly substituted novel 4H-pyrimido[1,6-a] pyrimidines were prepared by a trifluoromethanesulfonic acid catalyzed one-pot three-component condensation of 4-aminopyrimidines, aldehydes, and β-ketoesters. A preliminary feasibility study was undertaken on these compounds, to assess the potential production of a library of further diversified compounds by nucleophilic replacement of Cl (R1) or by reaction of electrophiles with the NH2 (R2) group. |
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