meso-Phbox-Pd(II) catalyzed tandem carbonylative cyclization of 1-ethynyl-1-propargyl acetate |
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| Authors: | Kato Keisuke Teraguchi Ryuhei Motodate Satoshi Uchida Akira Mochida Tomoyuki Peganova Tat'yana A Vologdin Nikolai V Akita Hiroyuki |
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| Institution: | Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan. kkk@phar.toho-u.ac.jp. |
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| Abstract: | Palladium(ii) catalyzed carbonylation of 1-ethynyl-1-propargyl acetate is described; in the absence of the bisoxazoline (box) ligand, the second triple bond did not react, affording cyclic orthoesters and . The use of meso-Phbox-Pd(ii) strikingly changed the course of the reaction, yielding bicyclic lactone by tandem carbonylative cyclization as a result of insertion of the second triple bond. |
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