Continuous flow enzyme-catalyzed polymerization in a microreactor |
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Authors: | Kundu Santanu Bhangale Atul S Wallace William E Flynn Kathleen M Guttman Charles M Gross Richard A Beers Kathryn L |
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Affiliation: | Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States. |
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Abstract: | Enzymes immobilized on solid supports are increasingly used for greener, more sustainable chemical transformation processes. Here, we used microreactors to study enzyme-catalyzed ring-opening polymerization of ε-caprolactone to polycaprolactone. A novel microreactor design enabled us to perform these heterogeneous reactions in continuous mode, in organic media, and at elevated temperatures. Using microreactors, we achieved faster polymerization and higher molecular mass compared to using batch reactors. While this study focused on polymerization reactions, it is evident that similar microreactor based platforms can readily be extended to other enzyme-based systems, for example, high-throughput screening of new enzymes and to precision measurements of new processes where continuous flow mode is preferred. This is the first reported demonstration of a solid supported enzyme-catalyzed polymerization reaction in continuous mode. |
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