Palladium-catalyzed C,N-cross coupling reactions of 3-halo-2-aminopyridines |
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| Authors: | Perez Felix Minatti Ana |
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| Institution: | Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799, USA. |
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| Abstract: | A simple approach toward N(3)-substituted-2,3-diaminopyridines is presented, based on Pd-catalyzed C,N-cross coupling. The use of RuPhos- and BrettPhos-precatalysts in combination with LiHMDS allows for C,N-cross coupling reactions of unprotected 3-halo-2-aminopyridines with primary and secondary amines. |
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