| Preparation of new technetium-99m NNS/X complexes and selection for brain imaging agent |
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| 引用本文： | HE Qiange,CHEN Xiangji,MIAO Yubin & LIU Boli Chemistry Department,Beijing Normal University,Beijing 100875,China. Preparation of new technetium-99m NNS/X complexes and selection for brain imaging agent[J]. 中国科学B辑(英文版), 2004, 47(6): 499-506. DOI: 10.1360/03yb0030 |
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| 作者姓名： | HE Qiange CHEN Xiangji MIAO Yubin & LIU Boli Chemistry Department Beijing Normal University Beijing 100875 China |
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| 作者单位： | HE Qiange，CHEN Xiangji，MIAO Yubin & LIU Boli Chemistry Department，Beijing Normal University，Beijing 100875，China |
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| 摘 要： | Quantification of regional cerebral blood flow(rCBF) plays an important role in the diagnosis ofvarious cerebrovascular and neurological diseases. Innuclear medicine, brain perfusion imaging can providesituation of whole or regional cerebral blood flowperfusion (CBF or rCBF) to neurologists, help to findabnormality of cerebral blood flow before cere-brovascular and neurological diseases induce patho-logical changes in configuration or structure of brain.They offer important information for …
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Preparation of new technetium-99m NNS/X complexes and selection for brain imaging agent |
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| HE Qiange,CHEN Xiangji,MIAO Yubin,LIU Boli. Preparation of new technetium-99m NNS/X complexes and selection for brain imaging agent[J]. Science in China(Chemistry), 2004, 47(6): 499-506. DOI: 10.1360/03yb0030 |
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| Authors: | HE Qiange CHEN Xiangji MIAO Yubin LIU Boli |
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| Affiliation: | Chemistry Department, Beijing Normal University, Beijing 100875, China |
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| Abstract: | Based on excellent experiment results of 99mTcO-MPBDA-Cl, two new ligands MPTDA and MPDAA are synthesized. Then series of 99mTcO3+ complexes are prepared through adding different halide anions, followed by tests of physical chemistry qualities and biodistribution experiments. And results of these experiments show that complexes formed with MPTDA and MPDAA have better lipophilicity than those formed with MPBDA, still maintain the good brain retention ability of this type of compounds, but radioactivity uptake in blood is higher than that of 99m TcO-MPBDA and ratios of brain/blood are reduced. Obvious affections are fetched out on brain uptake and retention if fluoride, bromide or iodide anions are added. Results of experiments can be explained in reason with theoretic computation. It is confirmed that 99m TcO-MPBDA-Cl has potential to develop a new type of brain imaging agent considering integrated factors such as brain uptake, retention and toxicity. |
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| Keywords: | mTc brain perfusion imaging agent MPBDA MPTDA MPDAA. |
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