Enantioselective Rh-catalyzed hydrogenation of 3-aryl-4-phosphonobutenoates with a P-stereogenic BoPhoz-type ligand |
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Authors: | Duan Zheng-Chao Hu Xiang-Ping Zhang Cheng Zheng Zhuo |
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Institution: | Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. |
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Abstract: | A series of chiral 3-aryl-4-phosphonobutyric acid esters were synthesized in high enantioselectivities (93-98% ee) via the Rh-catalyzed asymmetric hydrogenation of the corresponding 3-aryl-4-phosphonobutenoates using a P-stereogenic BoPhoz-type phosphine-aminophosphine ligand. The methodology has been successfully applied to the asymmetric synthesis of a potential GABA(B) antagonist, (R)-phaclofen, in high enantioselectivity. |
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