Synthesis of acyclic nucleoside phosphonates as antiviral compounds |
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| Authors: | Frank Wormstdt Michael Gütschow Kurt Eger Ute Brinckmann |
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| Institution: | Frank Wormstädt,Michael Gütschow,Kurt Eger,Ute Brinckmann |
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| Abstract: | Reaction of 6‐chloropyrimidines with diethyl (2‐aminoethoxy)methyl]phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5‐substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (HSV‐1 and HSV‐2) and human immunodeficiency virus (HIV‐1). Some compounds showed weak antiviral activity against HSV‐1. |
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