Abstract: | The crystal structure of a methanol–water solvate ofleurosine methiodide, (leurosine‐CH3)+I?·3CH3OH·2H2O (C47H59IN4O9·3CH3OH·2H2O), is described. The piperidine ring of the upper part of the molecule adopts a sofa conformation. An intramolecular hydrogen bond between the tertiary N and the hydroxyl group of the vindoline moiety of the molecule is present. |