Reactivity of N‐benzyl‐3‐nitrophthalimide: A facile access to isoindolo[1,2‐d][3,5]benzothiazocine derivatives

A functionalized isoindolo1,2‐d]3,5]benzothiazocine 2B has been synthesized in three steps from the nitro‐imide derivative 5. The key step of this sequence was the cyclization of the thioglycolic acid derivative 9 under acidic conditions. An evaluation of the reactivity of the imide 5 and the corresponding N‐acyliminium ion toward borohydride reduction, organometallic addition, Meyer‐Schuster rearrangement and intermolecular alkoxylation and thioalkoxylation reactions was reported.