Reactivity of N‐benzyl‐3‐nitrophthalimide: A facile access to isoindolo[1,2‐d][3,5]benzothiazocine derivatives |
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Authors: | Abderrahim Chihab‐Eddine Abderrahim Jilale Adam Daïch Bernard Decroix |
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Abstract: | A functionalized isoindolo1,2‐d]3,5]benzothiazocine 2B has been synthesized in three steps from the nitro‐imide derivative 5. The key step of this sequence was the cyclization of the thioglycolic acid derivative 9 under acidic conditions. An evaluation of the reactivity of the imide 5 and the corresponding N‐acyliminium ion toward borohydride reduction, organometallic addition, Meyer‐Schuster rearrangement and intermolecular alkoxylation and thioalkoxylation reactions was reported. |
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