cis‐[(4R,5R)‐4,5‐Bis(aminomethyl)‐2,2‐dimethyl‐1,3‐dioxolane‐N,N′](malonato‐O,O′)platinum(II), an anticancer agent |
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Authors: | Sang Woo Cho Yongkee Cho Dae‐Kee Kim Whanchul Shin |
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Abstract: | In the title compound, Pt(C3H2O4)(C7H16N2O2)], the Pt atom is coordinated to two O and two N atoms in a square‐planar arrangement. The two independent molecules, which have very similar structures, are approximately related by pseudo‐twofold screw‐axis symmetry. The six‐membered chelate ring in the leaving ligand assumes a conformation intermediate between the half‐chair and boat forms. The seven‐membered ring in the carrier ligand assumes a twist‐chair conformation and the oxolane ring assumes an envelope conformation. The crystal packing consists of extensive hydrogen‐bonding networks which form two‐dimensional molecular layers, and there are weak van der Waals interactions between these layers. |
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