Experimental and theoretical structural study of 2‐pyridyl‐ and 4‐hydroxyphenyl‐1,4‐dihydropyridine derivatives |
| |
| Authors: | Hctor Novoa De Armas Norbert Blaton Oswald M Peeters Camiel De Ranter Margarita Surez Emilio Rolando Yamila Verdecia Estael Ochoa Nazario Martín Margarita Quinteiro Carlos Seoane Jos L Soto |
| |
| Institution: | Héctor Novoa De Armas,Norbert Blaton,Oswald M. Peeters,Camiel De Ranter,Margarita Suárez,Emilio Rolando,Yamila Verdecia,Estael Ochoa,Nazario Martín,Margarita Quinteiro,Carlos Seoane,José L. Soto |
| |
| Abstract: | A series of substituted 1,4‐dihydropyridines (1,4‐DHPs) has been synthesised following the well‐known Hantzsch's procedure for symmetrical 1,4‐DHP. The structures of these compounds have been thoroughly studied by X‐ray crystallographic analysis and semiempirical (AMI) calculations. A good agreement is found between the theoretical and experimental results. In all cases, the most stable conformation fulfils all the requirements needed for exhibiting an antagonist calcium effect. |
| |
| Keywords: | |
|
|
