PHOTOSENSITIZATION BY ANTITUMOR AGENTS—1. PRODUCTION OF SINGLET OXYGEN DURING IRRADIATION OF ANTHRAPYRAZOLES WITH VISIBLE LIGHT |
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| Authors: | Krzysztof Reszka Petros G. Tsoungas J. William Lown |
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| Affiliation: | Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada |
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| Abstract: | Abstract— Oxygen consumption, photoinduced by visible light, and sensitized by novel anthrapyrazole antitumor agents has been observed. Generation of singlet oxygen upon irradiation of ethanolic solutions of the drugs with visible light (480–520 nm) was demonstrated using a specific 1O2 acceptor, 2.5-dimethylfuran and a quencher, sodium azide. An electron paramagnetic resonance method was employed to measure the rate of oxygen consumption. Significant differences were found in the sensitizing properties among the anthrapyrazoles studied. Intramolecular hydrogen bonding within the chro-mophore is one of the structural factors that determine the efficacy of a given anthrapyrazole in 1O2 generation |
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