A mathematical model of silicon-based thermobiosensors

A mathematical model of a silicon glucose thermobiosensor thatdetects changes in temperature produced by a biocatalytic reactionis proposed for calculation of transient temperature and reactantconcentration profiles, time-dependencies of the output signal,and calibration curves. Mathematically the model is reducedto a one-dimensional linear initial-boundary-value problem ofthe heat-conduction equation with a thermal source F(x, t).In order to find F(x, t), a system of the second-order nonlinearpartial differential equations for glucose and oxygen concentrations,describing a combination of diffusion-membrane theory and Michaelis-Mentenenzyme reaction theory, has been solved. The computed dependenciesof transient temperature profile and sensor response to variousconditions such as oxygen buffer concentration, membrane thickness,enzyme loading, and operation mode are analysed for the optimaldesign of the tensor.