Synthesis and in vivo study of metallofullerene based MRI contrast agent |
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| Authors: | Jun Zhang Kaimin Liu Gengmei Xing Tongxiang Ren Shukuan Wang |
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| Institution: | (1) School of Life Science and Technology, Beijing Institute of Technology, Beijing, 100081, P.R. China;(2) Laboratory for Bio-Environmental Health Sciences of Nanoscale Materials, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, P.R. China |
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| Abstract: | Gd@C82(OH)40 has been developed as a new generation of MRI contrast agent. But recently, it was found that Gd@C82(OH)
x
with a larger number of OH (x>36) would lead to cage break and hence, release of highly toxic Gd ions. We synthesized the more stable Gd@C82(OH)
x
with less OH-number, Gd@C82(OH)16, and studied its proton relaxivity and MRI images. The results indicate that Gd@C82(OH)16 also gives high proton relaxivity, even higher than that of (NMG)2-Gd-DTPA. The bio-distribution indicated that Gd@C82(OH)16 tends to be entrapped in the liver and kidney and remained in tissue for about 2 hours. The results suggest that the more
stable metallofullerene derivative Gd@C82(OH)16 can be the potential candidate of the new MRI contrast agent. |
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