Synthetic studies on cyathins: enantioselective total synthesis of (+)-allocyathin B2 |
| |
Authors: | Takano Masashi Umino Akinori Nakada Masahisa |
| |
Institution: | Department of Chemistry, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan. |
| |
Abstract: | reaction: see text] The enantioselective total synthesis of (+)-allocyathin B(2) has been achieved. Our approach features a convergent enantioselective construction of the 5-6-7 tricyclic core system using the originally developed chiral building blocks via asymmetric catalysis, the intramolecular aldol reaction in high yield, successful samarium diiodide-mediated ring expansion, and a newly developed double-bond installation method. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|