由1,1-二溴烯烃一锅法合成1,4-二取代-1,2,3-三氮唑

以1,1-二溴乙烯和芳基叠氮化合物为原料,碘化亚铜为催化剂,室温下通过一锅法合成了1,4-二取代-1,2,3-三氮唑衍生物。考察了催化剂用量、反应溶剂、反应温度对产品收率的影响。通过IR,MS,_¹H NMR及_¹³C NMR等对目标产物结构进行确证,并提出了可能的反应机理。该合成方法具有环境友好、条件温和、操作简单、收率高等特点。

One-Pot Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from 1,1-Dibromoalkenes

1,4-Disubstituted 1,2,3-Triazoles were synthesized by a CuI catalysed one-pot reaction using 1,1-dibromoalkenes and aryl azides as raw materials under room temperature. Effects of the amount of catalyst, solvent and the reaction temperature on the yields of product were studied. The structures of the 1,2,3-Triazoles were characterized by IR analysis, mass spectrometry, _¹H NMR and _¹³C NMR spectroscopy. A mechanism to rationalize the reaction was proposed. This method has the advantages of environment friendly, mild reaction conditions, simple one pot operation and high yields.