Insights into the synthesis and mechanism of green synthesized antimicrobial nanoparticles,answer to the multidrug resistance |
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| Authors: | D Sharma P Shandilya NK Saini P Singh VK Thakur RV Saini D Mittal G Chandan V Saini AK Saini |
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| Institution: | 1. School of Biological and Environmental Sciences, Faculty of Sciences, Shoolini University, Solan, HP, 173229, India;2. School of Chemistry, Faculty of Sciences, Shoolini University, Solan, HP, 173229, India;3. School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110 067, India;4. Biorefining and Advanced Materials Research Center, Scotland''s Rural College (SRUC), Kings Buildings, Edinburgh, EH9 3JG, UK;5. Department of Biotechnology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, 133207, India;6. Maharishi Markandeshwar University, Kumarhatti, Solan, Himachal Pradesh, 173229, India |
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| Abstract: | Emergence of the multidrug resistant human pathogenic strains is posing a serious health challenge. Resistant strains carry mutations which help them to resist conventional drugs. Therefore, it is required to produce more effective agents that are able to degrade the resistant pathogenic bacterial strains. The antimicrobial properties of nanoparticles (NPs) by eco-friendly green synthetic methods have pulled attention everywhere owing to their exceptional properties and small particle size of 100 nm. NPs are considered to belong to a group of antimicrobial agents which have ability to go inside microbial cells and kill them. In this comprehensive review, we are discussing the green synthetic methods used for the synthesis of NPs targeting the microbes. Additionally, several characterization techniques of antimicrobial NPs are also discussed. Subsequently, various methods used for the analysis of antimicrobial activities and their mechanisms are also examined. |
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| Keywords: | Nanoparticles DNA damage Bacterial species Antimicrobial activities Antimicrobial mechanisms Reactive oxygen species |
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