| 紫外分光光度法测定配合物组成及其在手性分离中应用 |
| |
| 引用本文： | 徐卉姝,关瑾,陈星,阎峰,谷亨达,石爽.紫外分光光度法测定配合物组成及其在手性分离中应用[J].光谱实验室,2010,27(3):972-976. |
| |
| 作者姓名： | 徐卉姝 关瑾 陈星 阎峰 谷亨达 石爽 |
| |
| 作者单位： | 沈阳化工学院应用化学学院,沈阳市经济开发区11号,110142 |
| |
| 基金项目： | 辽宁省教育厅基金，辽宁省自然基金资助项目 |
| |
| 摘 要： | 采用紫外分光光度法测定了Cu(Ⅱ)和L-组氨酸二元配合物的组成及Cu(Ⅱ)与L-组氨酸和泮托拉唑三元配合物组成,研究了配合物的紫外吸收光谱性质,考察了溶液pH对配合物稳定性的影响。Cu(Ⅱ)和L-组氨酸二元配合物的组成比为1∶2,Cu(Ⅱ)与L-组氨酸和泮托拉唑三元配合物组成比为1∶1∶1,碱性条件有利于配合物的生成。该结果应用于高效液相色谱法分离泮托拉唑对映体,分离度为1.4。
|
| 关 键 词： | 配合物 紫外分光光度法 泮托拉唑 手性分离 |
Determination of Composition of Complexs by UV Spectrophotometry and Its Application in Chiral Separation |
| |
| XU Hui-Shu,GUAN Jin,CHEN Xing,YAN Feng,GU Heng-Da,SHI Shuang.Determination of Composition of Complexs by UV Spectrophotometry and Its Application in Chiral Separation[J].Chinese Journal of Spectroscopy Laboratory,2010,27(3):972-976. |
| |
| Authors: | XU Hui-Shu GUAN Jin CHEN Xing YAN Feng GU Heng-Da SHI Shuang |
| |
| Institution: | (School of Applied Chemistry,Shenyang Institute of Chemical Technology,Shenyang 110142,P.R.China) |
| |
| Abstract: | The compositions of Cu（Ⅱ） and L-His binary complex and Cu（Ⅱ）-L-His and chiral drug ternary complex were determined by UV spectrophotomtry.The UV spectral property of complex was also studied.The effects of different pH of solution on the stability of complex were investigated.The ratios of composition of Cu（Ⅱ） and L-His binary complex and Cu（Ⅱ）-L-His and chiral drug ternary complex were 1：2 and 1：1：1,respectively.The complex was more stable under basic condition.The enantiomers of pantoprazole were separated with a resolution of 1.4 by high performance liquid chromatography with Cu（Ⅱ）-L-His as chiral additive on a conventional C18 column. |
| |
| Keywords: | Complex UV Spectrophotometry Patoprazole Chiral Separation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
