Alginate-Coated Fe3O4 Hollow Microspheres for Drug Delivery |
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| Authors: | Li-juan Dong Gu Jin |
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| Affiliation: | 1.College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China2.Department of Chemistry, University of Science and Technology of China, Hefei 230026, China |
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| Abstract: | Novel hollow Fe3O4 nanoparticles for drug delivery were synthesized via a one-step templatefree approach. These nanoparticles were obtained by modifing the Fe3O4 nanoparticles with 3-aminopropyltrimethoxy silane, and then grafting alginate onto the surface of amine magnetic. The hollow structure of Fe3O4 spheres was characterized by TEM, XRD, and XPS. The M-H hysteresis loop indicated that the magnetic spheres exhibit superparamagnetic characteristics at room temperature. Daunorubicin acting as a model drug was loaded into the carrier, and the maximum percent of envelop and load were 28.4% and 14.2% respectively. The drug controlled releasing behaviors of the carriers were compared in different pH media. |
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| Keywords: | Hollow Fe3O4 nanoparticles 3-Aminopropyltrimethoxy silane Drug delivery |
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