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Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture |
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| Authors: | Julian B. Chaudhuri Matthew G. Davidson Marianne J. Ellis Matthew D. Jones XuJun Wu |
| Affiliation: | 1. Centre for Regenerative Medicine, Department of Chemical Engineering, University of Bath, Claverton Down, Bath, UK, BA2 7AY;2. Department of Chemistry, University of Bath, Claverton Down, Bath, UK, BA2 7AY;3. Centre for Regenerative Medicine, Department of Chemical Engineering, University of Bath, Claverton Down, Bath, UK, BA2 7AY Department of Chemistry, University of Bath, Claverton Down, Bath, UK, BA2 7AY |
| Abstract: | Summary: Surfactant-free honeycomb-structured Poly(DL lactide) (PDL LA) and Poly-(DL lactide-co-glycolide) PDL LGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering. |
| Keywords: | biodegradable honeycomb scaffold thin film tissue engineering |