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Rheological Characterization of Self-Hardening Hydrogel for Tissue Engineering Applications: Gel Point Determination and Viscoelastic Properties |
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| Authors: | Ahmed Fatimi Monique A V Axelos Jean François Tassin Pierre Weiss |
| Institution: | 1. INSERM, U791, Université de Nantes, Laboratoire d'Ingénierie Ostéo-Articulaire et Dentaire, 1 place Alexis Ricordeau, 44042 Nantes, Cedex 01 France;2. INRA, UR1268, Biopolymères, Interactions, Assemblages, BP 71627, 44316 Nantes, Cedex 03, France;3. CNRS, Université du Maine, UMR 6120, Polymères, Colloïdes, Interfaces, avenue Olivier Messiaen, 72085 Le Mans, Cedex 9, France |
| Abstract: | Summary: Silated hydroxypropylmethylcellulose (Si-HPMC) is a modified biopolymer used in biomaterial's domain. A hydroxypropylmethylcellulose (HPMC) was functionalised with silane groups. The macromolecular solution of Si-HPMC (pH 12.9) generates an elastic state at physiological pH (∼7.4). In this work we present the gel formation of Si-HPMC resulting from the condensation of silanol groups. The crosslinked hydrogel was characterized using rheological techniques. With the scalar percolation model the gelation time was determined as a function of Si-HPMC concentration at 37 °C. |
| Keywords: | biomaterials cellulose gelation hydrogels rheology |