Nickel(II) complexes of thiosemicarbazones: synthesis,characterization, X-ray crystallographic studies and in vitro antitubercular and antimicrobial studies |
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Authors: | Priya P. Netalkar Sandeep P. Netalkar Vidyanand K. Revankar |
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Affiliation: | 1. Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad, 580 003, Karnataka, India
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Abstract: | Three nickel(II) thiosemicarbazone complexes have been synthesized and characterized by spectroscopic and physicochemical techniques. The molecular structures of two of the complexes have been determined by single-crystal X-ray diffraction studies. In both of these complexes, the nickel center is coordinated by two tridentate ligands in a meridional fashion using C=S, C=N and neutral hydroxyl OH donors. The ligand is bound to nickel in its thione form in all three complexes. The synthesized compounds were tested for antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi. Additionally, all the compounds were screened for antituberculosis activity. Several complex/organism combinations returned an MIC value of 0.8 μg/mL or better, which is almost 8 times more active than the standard (streptomycin, 6.25 μg/mL). |
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