Regioselective functionalization of trisubstituted pyridines using a bromine-magnesium exchange |
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| Authors: | Ren Hongjun Knochel Paul |
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| Institution: | Department Chemie, Ludwig-Maximilians-Universit?t München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany. |
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| Abstract: | A tosyloxy substituent in position 2 allows a highly regioselective Br/Mg exchange reaction on 3,5-dibromopyridine derivatives using iso-PrMgCl.LiCl. The resulting functionalized pyridylmagnesium reagents react with various electrophiles in position 3. Acylated pyridines of this type can be readily converted into pyrazolo 3,4-b] pyridines. |
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