A novel application of small-angle scattering techniques: Quality assurance testing of virus quantification technology |
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Institution: | 1. Biotechnology Division, NIST, 100 Bureau Drive, Stop 8311, Gaithersburg, MD 20899-8311, USA;2. Edgewood Chemical Biological Center; 5183 Blackhawk Road, Aberdeen Proving Ground, MD 21010, USA;3. NIST Center for Neutron Research, NIST, 100 Bureau Drive, Stop 6102, Gaithersburg, MD 20899-6102, USA |
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Abstract: | Small-angle scattering (SAS) techniques, like small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS), were used to measure and thus to validate the accuracy of a novel technology for virus sizing and concentration determination. These studies demonstrate the utility of SAS techniques for use in quality assurance measurements and as novel technology for the physical characterization of viruses. |
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