Preparation of thermosensitive membranes by radiation grafting of acrylic acid/N-isopropyl acrylamide binary mixture on PET fabric |
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| Institution: | 1. Joint Institute for Nuclear Research (JINR), Dubna, Russia;2. State Scientific Center \"Institute of High Energy Physics\" (IHEP), Protvino, Russia;3. Institute of Space Research, Magurele, Romania;4. P.N. Lebedev Physical Institute of the Russian Academy of Sciences (LPI RAS), Moscow, Russia;5. Southwestern University, Blagoevgrad, Bulgaria;6. Institute for Nuclear Research and Nuclear Energy, Sofia, Bulgaria;1. Joint Institute for Nuclear Research, Dubna, Moscow region, 141980, Russia;2. Dubna State University, 141980, Dubna, Moscow region, Russia;1. Laboratory of Radiation Biology, Joint Institute for Nuclear Research, 6 Joliot-Curie St., 141980 Dubna, Moscow Region, Russia;2. Biophysics Department, “Dubna” University, 19 Universitetskaya St., 141980 Dubna, Moscow Region, Russia;3. Academy of Sciences of Moldova, Chi?in?u, Moldova;4. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia;5. Zakusov Institute of Pharmacology, Moscow, Russia;6. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia |
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| Abstract: | Thermosensitive membranes were prepared by radiation-induced graft copolymerization of monomers on PET fabrics. A binary mixture of N-isopropyl acrylamide (NIPAAm) and acrylic acid (AA) was grafted on polyester fabric as a base material to introduce thermosensitive poly(N-isopropyl acrylamide) pendant chains having LCST slightly higher than 37 °C in the membrane. The influence of ferrous sulfate, radiation dose and monomer composition on the degree of grafting was studied. The structure of the grafted fabric was characterized by thermogravimetric analysis, differential scanning calorimetry and scanning electron microscopy. The thermosensitive nature of the fabric was monitored by swelling at different temperatures. The graft copolymerization of AA with NIPAAm enhanced the LCST of the resultant membrane to ～37 °C. The moisture vapor transmission rate (MVTR) and air permeability of the fabric decreased slightly, may be due to the slight blocking of the fabric pores. The immobilization of tetracycline hydrochloride as the model drug and its release characteristics at different temperatures were monitored. |
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