Effect of ventricle motion on the dynamic behaviour of chorded mitral valves |
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| Institution: | 1. Department of Engineering Science, University of Oxford, Oxford, UK;2. Department of Mathematics, University of Glasgow, Glasgow, UK;3. Department of Engineering Mechanics, Xi’an Jiaotong University, Xi’an, PR China;4. Department of Cardiac Surgery, University of Glasgow, Glasgow, UK;1. PETROBRAS Research and Development Center (CENPES), Avenida Horácio Macedo, 950, Cidade Universitária, ZIP 21941-915 RJ, Rio de Janeiro, Brazil;2. Mechanical Engineering Department, COPPE, EE, UFRJ – Federal University of Rio de Janeiro, PO Box 68503, ZIP 21945-970 RJ, Brazil;3. Civil and Computational Engineering Centre, College of Engineering, Swansea University, Swansea SA2 8PP, United Kingdom;1. Faculty of Computing, Universiti Teknologi Malaysia, Johor, Malaysia;2. UTM-IRDA Digital Media Center of Excellence, Universiti Teknologi Malaysia, Johor, Malaysia;3. Advance Informatics School, Universiti Teknologi Malaysia, Kuala Lumpur, Malaysia;4. Intelligent Software Laboratory, Iwate Prefectural University (IPU), Iwate, Japan;1. Centro Cardiovascular, Hospital de Clinicas, Universidad de la Republica, Montevideo, Uruguay;2. Insitut Universitaire de Cardiologie et de Peneumologie/Québec Heart and Lung Institute, Department of Cardiology, Quebec, Canada;1. Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy;2. Department of Medical and Surgical Sciences, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy;1. Computer, Electrical and Mathematical Science and Engineering Division (CEMSE) at King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia;2. Department of Biomedical, Industrial, and Human Factors Engineering, Wright State University, OH, United States |
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| Abstract: | An Immersed Boundary (IB) model is employed to investigate the dynamic behaviour of a novel chorded mitral prosthesis, which is in the early stages of its development, under physiological flow conditions. In vivo magnetic resonance images (MRIs) of the left ventricle are analysed to determine the relative motion of the mitral annulus and the papillary muscle regions of the ventricle. The dynamic boundary conditions are incorporated into IB simulations to test the valve in a more realistic dynamic geometric environment. The IB model has successfully identified the effect of the dynamic boundary conditions on the mechanical behaviour of the valve and revealed the strengths and weaknesses of the current mitral design. The mechanical performance of the prosthesis is compared with recent studies of native porcine valves; differences in mechanical behaviour are observed. Potential improvements for the design of the prosthesis are proposed. |
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