Multi-molecule reaction of serum albumin can occur through thiol-yne coupling |
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Authors: | Lo Conte Mauro Staderini Samuele Marra Alberto Sanchez-Navarro Macarena Davis Benjamin G Dondoni Alessandro |
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Institution: | Dipartimento di Chimica, Laboratorio di Chimica Organica, Universitá di Ferrara, via L. Borsari 46, 44100 Ferrara, Italy. |
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Abstract: | The free-radical hydrothiolation of alkynes (thiol-yne coupling, TYC) unites two thiol fragments across the carbon-carbon triple bond to give a dithioether derivative with exclusive 1,2-addition; this reaction can be used for modification of peptides and proteins allowing glycoconjugation and fluorescent labeling. These results have implications not only as a flexible strategy for attaching two modifications at a single site in proteins but also for unanticipated side-reactions of reagents (such as cycloalkynes) used in other protein coupling reactions. |
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