Reaction based fluorescent probes for hydrogen sulfide |
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| Authors: | Liu Chunrong Peng Bo Li Sheng Park Chung-Min Whorton A Richard Xian Ming |
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| Affiliation: | Department of Chemistry, Washington State University, Pullman, Washington 99164, USA. |
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| Abstract: | A reaction based fluorescence turn-on strategy for hydrogen sulfide (H(2)S) was developed. This strategy was based on a H(2)S-specific Michael addition-cyclization sequence. Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide. |
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