Nickel-catalyzed decarboxylative coupling of an alkynyl carboxylic acid with aryl iodides |
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| Authors: | Yujeong Son Han-Sung Kim Ju-Hyeon Lee Jisun Jang Chin-Fa Lee Sunwoo Lee |
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| Affiliation: | 1. Department of Chemistry, Chonnam National University, Gwangju 61186, Republic of Korea;2. Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan, ROC |
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| Abstract: | A decarboxylative coupling reaction with an alkynyl carboxylic acid and aryl iodides in the presence of a nickel catalyst was developed. When the reaction was conducted with NiCl2 (10 mol%), Xantphos (15 mol%), Mn (1.0 equiv), and Cs2CO3 (1.5 equiv), the desired diaryl alkynes were formed in moderated to good yields. Furthermore, this method does not produce the diyne, which is formed in the homocoupling of alkynyl carboxylic acids. |
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| Keywords: | Nickel Decarboxylative coupling Alkynyl carboxylic acid Aryl iodide Reductant |
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