One-pot synthesis of tricyclo-1,4-benzoxazines via visible-light photoredox catalysis in continuous flow |
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| Authors: | Guolin Wu Tingting Lv Wenhui Mo Xiping Yang Yu Gao Haijun Chen |
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| Institution: | College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China |
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| Abstract: | A facile one-pot synthesis of tricyclo-1,4-benzoxazines has been developed via metal-free intramolecular cyclization of indole derivates. These reactions were efficiently achieved at ambient temperature by using visible-light photoredox catalysis in continuous flow. This directed intramolecular cyclization could be easily handled and scaled up in an open flask, enabling construction of a focused compound library for further pharmacological evaluation. |
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| Keywords: | One-pot Flow chemistry Intramolecular cyclization Metal-free Room temperature |
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