Two new dimmeric xanthanolides isolated from Xanthium mogolium Kitag plant |
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| Authors: | Fuwang Xu Chengqian Xiao Xue Lv Min Lei Lihong Hu |
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| Affiliation: | 1. School of Pharmacy, East China University of Science and Technology, Shanghai, PR China;2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, PR China;3. Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China |
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| Abstract: | Two xanthanolide-type dimmers, namely Mogolide D (4) and Mogolide E (5) are isolated from the aerial parts of Xanthium mogolium Kitag plant collected from Heilongjiang province, China. The dimmers’ relative structures are elucidated on the basis of HRESIMS, IR spectrum and NMR spectroscopy. The absolute configurations of them are assigned with ECD spectra. The biosynthetic pathway of the two dimmers is also proposed. Besides, Mogolide D (4) and Mogolide E (5) are tested against MDA-MB-231 breast cancer cell line with IC50 8.46 μM and 19.20 μM, respectively. |
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| Keywords: | Xanthanolide Mogolide D Mogolide E Xanthatin Corresponding authors at: School of Pharmacy, East China University of Science and Technology, Shanghai, PR China. |
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