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A general approach to access 5,6-dihydroindolo-naphthyridine ring system |
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| Authors: | Shuwen He Peng Li Xing Dai Hong Liu Zhong Lai Dong Xiao Casey C. McComas Chunyan Du Yuehui Liu Jingjun Yin Qun Dang Nicolas Zorn Xuanjia Peng Ravi P. Nargund Anandan Palani |
| Affiliation: | 1. Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA;2. WuXi Apptec Co., Ltd, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China;3. Discovery Chemistry, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486, USA;4. Discovery Process Chemistry, Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA |
| Abstract: | We report a general approach for the synthesis of 5,6-dihydroindolo-naphthyridine ring system via an intramolecular cyclization of the indole NH to an alkene moiety as the key step. |
| Keywords: | Intramolecular cyclization 5,6-dihydroindolo-naphthyridine ring system Indole Alkene |
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