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A general approach to access 5,6-dihydroindolo-naphthyridine ring system |
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| Authors: | Shuwen He Peng Li Xing Dai Hong Liu Zhong Lai Dong Xiao Casey C McComas Chunyan Du Yuehui Liu Jingjun Yin Qun Dang Nicolas Zorn Xuanjia Peng Ravi P Nargund Anandan Palani |
| Institution: | 1. Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA;2. WuXi Apptec Co., Ltd, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China;3. Discovery Chemistry, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486, USA;4. Discovery Process Chemistry, Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA |
| Abstract: | We report a general approach for the synthesis of 5,6-dihydroindolo-naphthyridine ring system via an intramolecular cyclization of the indole NH to an alkene moiety as the key step. |
| Keywords: | Intramolecular cyclization 5 6-dihydroindolo-naphthyridine ring system Indole Alkene |
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