NMR studies on chiral intermediates in the total synthesis of (+)‐biotin from D‐mannose |
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| Authors: | Wen‐xue Chen Ping Zhang Fen‐er Chen |
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| Affiliation: | Department of Chemical, Fudan University, Shanghai 200433, China |
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| Abstract: | The chemical structure and stereochemistry of 12 intermediates in the total synthesis of (+)‐biotin starting from D ‐mannose as chiral pool were completely assigned using one‐ and two‐dimensional NMR experiments, including 1D selective NOE, DEPT, COSY, HSQC and HMBC. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | NMR 1H NMR 13C NMR 1D NOE (+)‐biotin D‐mannose |
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