A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation |
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Authors: | Amit N Pandya Eric M Villa E Jeffrey North |
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Institution: | 1. Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, NE, USA;2. Department of Chemistry, Creighton University, Omaha, NE 68178, USA |
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Abstract: | A simple and efficient approach for the synthesis of 2-aminoquinazoline derivatives in moderate to good yields. This reaction employs mild reaction conditions, is metal-free and utilizes readily available starting materials making it a more viable reaction for scale up synthesis and ligand diversity. Notably, this methodology allows for the synthesis of 2-aminoquinazolines using a free amine or cyclic amine enabling structural diversity and good atom economy. |
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Keywords: | Quinazolines Oxidative annulation Metal free Heteroaromatic |
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