Palladium-catalyzed convenient one-pot synthesis of multi-substituted 2-pyrones via transesterification and alkenylation of enynoates |
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| Authors: | Ramdas S Pathare Shivani Sharma Kandasamy Gopal Devesh M Sawant Ram T Pardasani |
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| Institution: | 1. Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Kishangarh 305 817, Rajasthan, India;2. Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Kishangarh 305 817, Rajasthan, India |
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| Abstract: | An efficient one-pot protocol for the synthesis of multi-substituted 2-pyrone derivatives from internal alkynes and unactivated alkenes is reported. The methodology involves difunctionalization of internal alkynes by using Pd(II) as a catalyst alongwith X-Phos as ligand via 6-endo transesterification and subsequent alkenylation pathway. Notable features include simple and easily available starting materials, including a range of unactivated alkenes, reduced synthetic steps and mild reaction conditions with high efficiency. |
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| Keywords: | Palladium Enynoates 2-Pyrones |
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